Why the study?
The study was conducted to assess the association of systolic blood pressure and diastolic blood pressure with mortality among older adults in Singapore.
Does the level of systolic and diastolic blood pressure affect all-cause mortality in community-dwelling older adults?
Population
4443 older adults (69.5±7.4 years; 60–97 years) in a nationally representative study in Singapore
Comparison
Different SBP and DBP categories vs reference ranges (SBP 100–119 mmHg, DBP 70–79 mmHg)
Design
Prospective observational study
Follow-up
2009 through end-December 2015
Key result
Compared to SBP 100-119 mmHg, mortality risk was significantly higher at extremes of SBP, including <100 mmHg (HR 2.41; 1.23-4.72) and ≥180 mmHg (HR 1.78; 1.12-2.81) among older adults.
Authors
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SBP extremes warrant caution in older adults; supports U-shaped curve but leaves optimal targets open for trials.
Observational (n=4,443)
Does the level of systolic and diastolic blood pressure affect all-cause mortality in community-dwelling older adults?
Effect estimate: HR 2.41 (95% CI 1.23-4.72)
Both excessively high and low systolic and diastolic blood pressures are associated with increased all-cause mortality in community-dwelling older adults, demonstrating a U-shaped risk curve.
Lian et al. (2021) conducted an observational in Community-dwelling older adults (n=4,443). Systolic and diastolic blood pressure vs. SBP 100-119 mmHg and DBP 70-79 mmHg was evaluated on All-cause mortality (HR 2.41, 95% CI 1.23-4.72). Compared to SBP 100-119 mmHg, mortality risk was significantly higher at extremes of SBP, including <100 mmHg (HR 2.41; 1.23-4.72) and ≥180 mmHg (HR 1.78; 1.12-2.81) among older adults.