Key result
Multi-domain lifestyle intervention cuts stroke and TIA risk ~29% vs general health advice in older adults.
Why the study?
Joint prevention of cardiovascular disease and dementia could reduce the burden of both conditions, but the effect of a multi-domain lifestyle intervention on incident cardiovascular disease needed assessment.
Does a 2-year multi-domain lifestyle intervention reduce incident cardiovascular disease in older adults aged 60-77 years?
RCT (n=1,259)
1:1
Does a 2-year multi-domain lifestyle intervention reduce incident cardiovascular disease in older adults aged 60-77 years?
Effect estimate: HR 0.80 (95% CI 0.61-1.04)
Absolute Event Rate: 17% vs 19.4%
A 2-year multi-domain lifestyle intervention in older adults significantly reduces the risk of cerebrovascular events, with broader cardiovascular benefits observed in patients with a prior history of CVD.
Authors
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“We have shown that multidomain interventions are effective and feasible. Now we are moving to precision prevention, optimizing and adapting FINGER for different target populations.”
“Much previous research has shown that there are links between cognitive decline in older people and factors such as diet, heart health, and fitness. However, our study is the first large randomized controlled trial to show that an intensive programme aimed at addressing these risk factors might be able to prevent cognitive decline in elderly people who are at risk of dementia.”
“This is a real experiment. The method of selection of patients and the randomization minimized biases.”
May reduce cerebrovascular events in at-risk older adults; leaves open effects on total CVD.
Lehtisalo et al. (2022) conducted an RCT in Cardiovascular disease and cognitive impairment (n=1,259). Multi-domain lifestyle intervention (diet, physical and cognitive activity, and vascular monitoring) vs. General health advice was evaluated on Incident CVD (total CVD events) (HR 0.80, 95% CI 0.61-1.04). A 2-year multi-domain lifestyle intervention in older adults reduced the incidence of combined stroke/TIA (HR 0.71; 95% CI 0.51-0.99) compared to general health advice.
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