Key result
Higher pulse pressure links to greater global WMH volume, indirectly relating to dementia diagnosis.
Why the study?
Individuals with Down syndrome are less likely to have hypertension, but whether blood pressure measures associate with brain health and clinical outcomes has not been studied in detail.
Is higher pulse pressure associated with cerebrovascular disease, neurodegeneration, and dementia in adults with Down syndrome?
Population
195 adults with Down syndrome (age 50.6±7.2 years, 44% women, 18% with dementia)
Comparison
Higher vs lower pulse pressure
Design
Observational cohort study
Authors
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May support vascular contributions to dementia in Down syndrome; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=195)
Yes
Is higher pulse pressure associated with cerebrovascular disease, neurodegeneration, and dementia in adults with Down syndrome?
Effect estimate: β 0.191 (95% CI 0.006-0.135)
p-value: p=0.032
In adults with Down syndrome, higher pulse pressure is associated with increased white matter hyperintensities, which may indirectly promote neurodegeneration and dementia.
Rizvi et al. (2023) conducted a cross-sectional in Down syndrome (n=195). Pulse pressure was evaluated on Global white matter hyperintensity (WMH) volume (β 0.191, 95% CI 0.006-0.135, p=0.032). Higher pulse pressure was associated with greater global white matter hyperintensity volume (β 0.191, p=0.032) and indirectly related to dementia diagnosis through parieto-occipital WMH.
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