Universal Hepatitis B Vaccination in Taiwan and the Incidence of Hepatocellular Carcinoma in Children
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Implication
Nationwide analysis reveals declining hepatocellular carcinoma rates in children after hepatitis B vaccination in Taiwan, indicating successful public health intervention.
Key Points
- This research aims to assess the impact of Taiwan's hepatitis B vaccination program on hepatocellular carcinoma incidence in children.
- Analyzed liver cancer data from Taiwan's National Cancer Registry and 17 major medical centers.
- Focused on children aged six years and older to exclude hepatoblastoma cases.
- Collected mortality data related to liver cancer among children.
- Average annual incidence of hepatocellular carcinoma in children aged 6 to 14 dropped from 0.70 to 0.36 per 100,000 from 1981 to 1994 (P<0.01).
- Mortality rates from hepatocellular carcinoma in children also decreased over the same period.
- Incidence in children aged 6 to 9 fell from 0.52 for those born 1974-1984 to 0.13 for those born 1984-1986 (P<0.001).
Cite This Study
Chang et al. (1997) studied this question.