Absence of >10% nighttime blood pressure reduction in hypertensive patients was associated with higher LV mass index compared to those with a normal nighttime reduction (98.3 vs 83.5 g/m2; p=0.002).
Cross-Sectional (n=235)
Does the absence of nocturnal blood pressure dipping increase left ventricular mass index in patients with essential hypertension?
The absence of nocturnal blood pressure dipping in patients with essential hypertension is associated with significantly greater left ventricular hypertrophy, independent of daytime blood pressure levels.
Absolute Event Rate: 98.3% vs 83.5%
p-value: p=0.002
The effects of circadian blood pressure (BP) changes on the echocardiographic parameters of left ventricular (LV) hypertrophy were investigated in 235 consecutive subjects (137 unselected untreated patients with essential hypertension and 98 healthy normotensive subjects) who underwent 24-hour noninvasive ambulatory blood pressure monitoring (ABPM) and cross-sectional and M-mode echocardiography. In the hypertensive group, LV mass index correlated with nighttime (8:00 PM to 6:00 AM) systolic (r = 0.51) and diastolic (r = 0.35) blood pressure more closely than with daytime (6:00 AM to 8:00 PM) systolic (r = 0.38) and diastolic (r = 0.20) BP, or with casual systolic (r = 0.33) and diastolic (r = 0.27) BP. Hypertensive patients were divided into two groups by presence (group 1) and absence (group 2) of a reduction of both systolic and diastolic BP during the night by an average of more than 10% of the daytime pressure. Casual BP, ambulatory daytime systolic and diastolic BP, sex, body surface area, duration of hypertension, prevalence of diabetes, quantity of sleep during monitoring, funduscopic changes, and serum creatinine did not differ between the two groups. LV mass index, after adjustment for the age, the sex, the height, and the daytime BP differences between the two groups (analysis of covariance) was 82.4 g/m2 in the normotensive patient group, 83.5 g/m2 in hypertensive patients of group 1 and 98.3 g/m2 in hypertensive patients of group 2 (normotensive patients vs. group 1, p = NS; group 1 vs. group 2, p = 0.002).(ABSTRACT TRUNCATED AT 250 WORDS)
Verdecchia et al. (1990) conducted a cross-sectional in Essential hypertension (n=235). Absence of >10% nighttime BP reduction vs. Presence of >10% nighttime BP reduction was evaluated on Left ventricular mass index (p=0.002). Absence of >10% nighttime blood pressure reduction in hypertensive patients was associated with higher LV mass index compared to those with a normal nighttime reduction (98.3 vs 83.5 g/m2; p=0.002).