Key result
Exercise-induced weight loss reduces proatherogenic lipoproteins while endurance training alone increases HDL-C.
Why the study?
Do exercise training and weight loss, independently or combined, improve lipoproteins and dyslipidemia in overweight sedentary men?
RCT (n=60)
randomized
Do exercise training and weight loss, independently or combined, improve lipoproteins and dyslipidemia in overweight sedentary men?
p-value: p=<0.001
Exercise-induced weight loss reduces proatherogenic lipoproteins, while exercise without weight loss improves factors involved in reverse cholesterol transport in overweight sedentary men.
Target weight loss with exercise to lower atherogenic lipoproteins in overweight men; extends prior trials by isolating training effects on HDL particles.
Both exercise training and weight loss reduce cardiovascular risk, but the independent importance of the two strategies is unclear. We aimed to investigate independent and combined effects of exercise training and weight loss on lipoproteins and dyslipidemia in overweight sedentary men. Sixty individuals were randomized to 12 wk of endurance training (T), energy-reduced diet (D), training and energy increased diet (T-iD), or control (C). Equal energetic deficits (-600 kcal/day) were prescribed by exercise for T and caloric restriction for D. T-iD completed similar exercise but remained in energy balance due to the dietary replacement of calories expended during exercise. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (apo)B and A1, pre-β-HDL, and susceptibility of LDL-C to oxidation were measured. Body weight was reduced similarly between T (-5.9 ± 0.7 kg) and D (-5.2 ± 0.8 kg), whereas T-iD (-1.0 ± 0.5 kg) and C (0.1 ± 0.6 kg) remained weight stable. Plasma TC, LDL-C, and apolipoprotein B were reduced in T compared with C ( P < 0.001 for both), but this was not observed for D ( P > 0.17). Changes in TC and LDL-C were associated with changes in body weight and body fat ( P < 0.01). In T-iD, increases in HDL-C and apolipoprotein A1 were observed ( P < 0.001). In conclusion, an exercise-induced decline in body weight reduces proatherogenic apoB-containing lipoproteins, whereas exercise compensated by energy intake increases the key component of reverse cholesterol transport, i.e., apoA1-containing HDL-C. NEW & NOTEWORTHY Exercise has additive effects in lowering plasma lipoprotein particles to diet-induced weight loss in individuals with increased cardiovascular risk. In the present study, we investigated whether training per se would have beneficial cardiovascular effects. We found that 3 mo of exercise-induced weight loss reduced proatherogenic lipoproteins, whereas endurance training without weight loss improved factors involved in reverse cholesterol transport in a group of overweight sedentary men.
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Rosenkilde et al. (2018) conducted an RCT in Overweight sedentary (n=60). Endurance training, energy-reduced diet, or training with energy-increased diet vs. Control was evaluated on Lipoproteins and dyslipidemia (TC, LDL-C, HDL-C, apoB, apoA1, pre-β-HDL, and LDL-C oxidation) (p=<0.001). Exercise-induced weight loss reduced proatherogenic lipoproteins (TC, LDL-C, apoB; P<0.001 vs control), whereas endurance training without weight loss increased HDL-C and apoA1 (P<0.001).
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