Key result
Higher triglycerides linked to ~2% greater MACE risk per 10 mg/dL in diabetics.
Why the study?
Does serum triglycerides level predict first cardiovascular events in diabetic patients with hypercholesterolemia and retinopathy?
Population
5042 participants with diabetes mellitus, hypercholesterolemia, and retinopathy from the EMPATHY study
Design
Cohort, randomized (original trial design), open-label, blinded-endpoint
Follow-up
Median three years
Authors
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May refine CV risk stratification in statin-treated diabetics; leaves open whether triglyceride lowering reduces events.
RCT (n=5,042)
open-label, blinded-endpoint
randomized
Yes
Does serum triglycerides level predict first cardiovascular events in diabetic patients with hypercholesterolemia and retinopathy?
Effect estimate: HR 1.021 per 10 mg/dl (95% CI 1.007-1.035)
p-value: p=0.0025
Higher serum triglyceride levels independently predict an increased risk of first cardiovascular events in high-risk diabetic patients with hypercholesterolemia and retinopathy.
Tada et al. (2018) conducted an RCT in diabetes mellitus with hypercholesterolemia and retinopathy (n=5,042). Serum triglycerides was evaluated on major adverse cardiac events including myocardial infarction, stroke, or cardiac death (HR 1.021 per 10 mg/dl, 95% CI 1.007-1.035, p=0.0025). Higher serum triglycerides were significantly associated with an increased risk of major adverse cardiac events in diabetic patients (adjusted HR 1.021 per 10 mg/dl; 95% CI 1.007-1.035; p=0.0025).
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