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September 30, 2008Cancer ResearchOpen Access

Runx2 Transcriptional Activation of Indian Hedgehog and a Downstream Bone Metastatic Pathway in Breast Cancer Cells

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Authors

JPJitesh PratapRush University Medical CenterJWJohn J. WixtedBeth Israel Deaconess Medical CenterTGTripti GaurIndian Institute of Technology Guwahati

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Pratap et al. (2008) studied this question.

synapsesocial.com/papers/6a09eeb4818b42a7b433f04ahttps://doi.org/10.1158/0008-5472.can-08-1078
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Smad3 Interacts with JunB and Cbfa1/Runx2 for Transforming Growth Factor-β1-stimulated Collagenase-3 Expression in Human Breast Cancer Cells2004 · 132 citations
  2. 2Fidelity of Runx2 Activity in Breast Cancer Cells Is Required for the Generation of Metastases-Associated Osteolytic Disease2004 · 147 citations
  3. 3Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo2005 · 188 citations
  4. 4<i>Runx2</i> and <i>MYC</i> Collaborate in Lymphoma Development by Suppressing Apoptotic and Growth Arrest Pathways <i>In vivo</i>2006 · 101 citations
  5. 5Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of <i>Indian hedgehog</i>2004 · 586 citations