Effectiveness and Safety of Digoxin Among Contemporary Adults With Incident Systolic Heart Failure
Key result
Incident digoxin use in adults with systolic heart failure was associated with higher mortality (HR 1.72, 95% CI 1.25-2.36) but no difference in heart failure hospitalization (HR 1.05).
Why the study?
Does incident digoxin use affect mortality and heart failure hospitalization in adults with incident systolic heart failure?
Population
2,891 adults with incident systolic heart failure between 2006 and 2008 within Kaiser Permanente Northern…
Comparison
Incident digoxin use vs No digoxin use
Design
Cohort
Follow-up
median 2.5 years
Authors
Discussion
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Member takes
Implication
Warrants caution with incident digoxin in systolic HF; challenges older trial-based guidelines and leaves open need for contemporary RCTs.
Structured PICO
Does incident digoxin use affect mortality and heart failure hospitalization in adults with incident systolic heart failure?
P
Population
2,891 adults with incident systolic heart failure between 2006 and 2008 within Kaiser Permanente Northern California who had no prior digoxin use.
I
Intervention
Incident digoxin use
C
Comparator
No digoxin use
O
Outcome
Death and heart failure hospitalizationhard clinical
In a contemporary cohort of patients with incident systolic heart failure, digoxin use was associated with increased mortality and no reduction in heart failure hospitalizations, challenging current guideline recommendations based on older trial data.
Cite This Study
Freeman et al. (2013) studied this question. Incident digoxin use in adults with systolic heart failure was associated with higher mortality (HR 1.72, 95% CI 1.25-2.36) but no difference in heart failure hospitalization (HR 1.05).