Key result
Id mRNA expression is regulated during post-natal development in rat ventricular myocytes and can be rapidly reinduced by an alpha-adrenergic agonist, suggesting a role in controlling cardiac phenotype.
Population
Rat ventricular myocytes (in vitro and during post-natal development)
Comparison
Alpha-adrenergic agonist (hypertrophic stimulus) vs Absence of serum/stimulus
Design
Preclinical
Authors
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Hypothesis-generating for Id in cardiac phenotype control; leaves open any role in human disease.
The transcriptional regulator Id is dynamically expressed during cardiac development and reactivated by hypertrophic stimuli, suggesting a role in controlling cardiac muscle cell phenotype.
Springhorn et al. (1992) studied Cardiac development and hypertrophy. alpha-adrenergic agonist vs. absence of serum / baseline was evaluated on Id mRNA expression and protein synthesis. Id mRNA expression is regulated during post-natal development in rat ventricular myocytes and can be rapidly reinduced by an alpha-adrenergic agonist, suggesting a role in controlling cardiac phenotype.
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