Why the study?
Persistent cardiac fibrosis leads to heart failure, but an effective treatment strategy has not yet been established.
Design
Review
Key result
This review summarizes the role of various ion channels, including TRP, Piezo1, and CRAC, in myocardial fibroblast activation and cardiac fibrosis to identify potential new therapeutic targets.
Authors
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May support ion channel targeting to limit fibrosis; hypothesis-generating pending clinical trials.
Ion channels in cardiac fibroblasts play a critical role in the development of myocardial fibrosis and may serve as novel therapeutic targets to prevent heart failure.
Xing et al. (2023) conducted a review in Cardiac fibrosis. Ion channels (TRP, Piezo1, CRAC, VGCCs, sodium, potassium) was evaluated. This review summarizes the role of various ion channels, including TRP, Piezo1, and CRAC, in myocardial fibroblast activation and cardiac fibrosis to identify potential new therapeutic targets.