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January 1, 1978The Journal of PhysiologyOpen Access

The Potassium Current Underlying Delayed Rectification in Cat Ventricular Muscle

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Key result

In cat ventricular muscle, the time-dependent outward current was separated into a fast component (IK) and a slow component (Ix), with IK displaying inward-going rectification.

Population

Cat ventricular muscle fibres

Design

Preclinical

Authors

TMTerence F. McDonaldDalhousie UniversityWTW. TrautweinGoethe University Frankfurt

Discussion

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Overview

Extends delayed rectifier characterization to ventricular muscle; leaves open translation to human electrophysiology.

Structured PICO

P
Population
Cat ventricular muscle fibres
I
Intervention
Voltage clamp using single sucrose gap method with varying external potassium concentrations (3 to 30 mM)
O
Outcome
Characteristics of outward potassium currents (I(K) and I(x)) including voltage dependence and current-voltage relationssurrogate

This study characterizes the fast and slow components of delayed rectifier potassium currents in cat ventricular muscle, highlighting similarities to Purkinje fiber currents.

Limitations

  • K accumulation during the activation of Ix may preclude an accurate determination of its time course and reversal potential.
  • Shifts in VK due to K accumulation precluded complete activations.
  • K accumulation during activation of I(x) may preclude accurate determination of its time course and reversal potential
  • Depletion of extracellular K from regions of restricted diffusion complicates detection of inward going I(K) tails

Cite This Study

McDonald et al. (1978) studied Cat ventricular muscle electrophysiology. Varying external K concentration was evaluated on Outward currents (IK and Ix). In cat ventricular muscle, the time-dependent outward current was separated into a fast component (IK) and a slow component (Ix), with IK displaying inward-going rectification.

synapsesocial.com/papers/6a0a1d514b13cba79251956chttps://doi.org/10.1113/jphysiol.1978.sp012144
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Membrane currents in cat myocardium: separation of inward and outward components1978 · 121 citations
  2. 2Extracellular Potassium Accumulation and Inward-Going Potassium Rectification in Voltage Clamped Ventricular Muscle1976 · 31 citations
  3. 3Reconstruction of the electrical activity of cardiac Purkinje fibres.1975 · 564 citations
  4. 4Membrane currents underlying delayed rectification and pace‐maker activity in frog atrial muscle1969 · 113 citations
  5. 5Potassium accumulation and depletion in frog atrial muscle.1976 · 79 citations