Key result
Inhibiting free radical accumulation during myocardial ischemia/reperfusion with scavengers reduces the severity of myocardial stunning, irreversible injury, and reperfusion arrhythmias.
Why the study?
Do free radical scavengers and inhibitors reduce reperfusion abnormalities in experimental models of myocardial ischemia/reperfusion?
Population
Experimental models of myocardial ischemia and reperfusion
Design
Review
Authors
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Supports antioxidant strategies in experimental reperfusion models; leaves open clinical translation.
Do free radical scavengers and inhibitors reduce reperfusion abnormalities in experimental models of myocardial ischemia/reperfusion?
This review highlights the pathophysiological role of oxygen free radicals in cardiac reperfusion injury and the potential therapeutic benefit of free radical scavengers.
Goldhaber et al. (1992) conducted a review in Myocardial ischemia and reperfusion abnormalities. Free radical scavengers and inhibitors was evaluated. Inhibiting free radical accumulation during myocardial ischemia/reperfusion with scavengers reduces the severity of myocardial stunning, irreversible injury, and reperfusion arrhythmias.
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