Key result
Cardiovascular symptoms or signs were significantly more common in children with heart lesions requiring intervention compared to those not requiring intervention (85% vs 32%, P<0.0001).
Why the study?
Does the presence of cardiovascular symptoms and signs predict significant congenital heart lesions requiring intervention in children with cardiac murmurs?
Population
223 children presenting with cardiac murmurs
Comparison
Presence of cardiovascular symptoms and signs vs Absence of cardiovascular symptoms and signs
Design
Case-control
Authors
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Symptoms and signs may aid triage of pediatric murmurs; leaves open prospective validation of age-specific predictive values.
Observational (n=223)
Does the presence of cardiovascular symptoms and signs predict significant congenital heart lesions requiring intervention in children with cardiac murmurs?
Absolute Event Rate: 85% vs 32%
p-value: p=<0.0001
Clinical assessment of cardiovascular symptoms and signs remains highly useful for identifying significant congenital heart lesions in children with murmurs, though predictive values vary by age.
Koo et al. (2008) conducted an observational in Cardiac murmurs (n=223). Significant congenital heart lesions requiring intervention vs. Congenital heart conditions not requiring intervention was evaluated on Presence of clinical symptoms or signs (p=<0.0001). Cardiovascular symptoms or signs were significantly more common in children with heart lesions requiring intervention compared to those not requiring intervention (85% vs 32%, P<0.0001).
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