What question did this study set out to answer?

The study aims to produce hybrid cells that can generate antibodies against the influenza virus.

July 1, 1977Proceedings of the National Academy of Sciences161 citationsOpen Access

Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells.

HKHilary Koprowski WGWalter Gerhard CCC M Croce

Puntos clave

The study aims to produce hybrid cells that can generate antibodies against the influenza virus.
Created somatic cell hybrids from mouse myeloma and spleen cells of an immunized BALB/c mouse.
Assessed antibody production specific to the hemagglutinin of influenza virus.
Evaluated tumor formation upon injection into BALB/c mice.
Hybrid cells produced large amounts of antibodies specific for the influenza virus hemagglutinin.
Injections of hybrid cells into BALB/c mice led to tumor formation.

Resumen

We have produced somatic cell hybrids between mouse myeloma cells and spleen cells derived from a BALB/c mouse immunized with purified influenza virus. The hybrid cells were found to produce large amounts of antibodies specific for the hemagglutinin of the virus and were able to induce tumor formation when injected into BALB/c mice.

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