Elevated troponin I (>0.04 ng/mL) significantly increased the risk of 28-day mortality compared to normal levels in patients with sepsis and organ dysfunction (83.4% vs. 16.2%, RR 5.74).
Cohort (n=200)
No
Does elevated cardiac troponin I (>0.04 ng/mL) predict 28-day mortality in patients with sepsis and organ dysfunction?
Cardiac troponin I measured at admission is a highly accurate prognostic biomarker (AUC 0.986) for predicting 28-day mortality in patients with sepsis and organ dysfunction.
Effect estimate: RR 5.74
Absolute Event Rate: 83.4% vs 16.2%
p-value: p=<0.001
Introduction and aim Sepsis is a complex, life-threatening condition characterized by systemic inflammation and multiorgan dysfunction. Elevated troponin levels (cTnI) have been associated with poor outcomes in sepsis; however, their role as a prognostic biomarker requires further investigation. This study aimed to (1) determine the association between elevated cardiac troponin I (>0. 04 ng/mL) and 28-day mortality in patients with sepsis and organ dysfunction, and (2) evaluate the prognostic accuracy of troponin I for mortality prediction in this population. Methods We conducted a prospective cohort study involving 200 sepsis patients, measuring troponin levels at admission time and clinical and biochemical parameters, such as Sequential Organ Failure Assessment (SOFA) scores, D-dimer, and lactate. Data on organ dysfunction, coagulation abnormalities, and patient outcomes (mortality, length of ICU stay) were collected and analyzed. Results Troponin I levels were elevated in 69% of patients and were significantly associated with increased mortality (115 83. 4% vs. 10 16. 2%; p0. 04 ng/mL demonstrated remarkable accuracy, achieving an AUC of 0. 986 in receiver operating characteristic (ROC) analysis. Conclusion Troponin I serves as a readily accessible and prognostically significant biomarker that improves early risk assessment in patients experiencing sepsis with organ dysfunction.
LNU et al. (Thu,) conducted a cohort in Sepsis and organ dysfunction (n=200). Elevated Troponin I (>0.04 ng/mL) vs. Normal Troponin I (≤0.04 ng/mL) was evaluated on 28-day mortality (RR 5.74, p=<0.001). Elevated troponin I (>0.04 ng/mL) significantly increased the risk of 28-day mortality compared to normal levels in patients with sepsis and organ dysfunction (83.4% vs. 16.2%, RR 5.74).