Key result
Major depressive disorder linked to ~49% greater T2DM risk versus general controls.
Why the study?
Does major depressive disorder increase the risk of type 2 diabetes mellitus compared to the general population?
Meta-Analysis (n=158,834)
Does major depressive disorder increase the risk of type 2 diabetes mellitus compared to the general population?
Major depressive disorder is associated with a significantly increased risk of type 2 diabetes mellitus compared to the general population, highlighting the need for targeted screening in this high-risk group.
Answers are grounded in this paper and cite their sources.
May inform diabetes risk stratification in major depressive disorder; leaves open causal mechanisms and screening changes.
BACKGROUND: Patients with depression may be at increased risk of type 2 diabetes mellitus (T2DM), which is a risk factor for cardiovascular diseases and premature mortality. We aimed to clarify the prevalence and predictors of T2DM in patients with major depressive disorder (MDD) and where possible compare the prevalence of T2DM in those with MDD versus general population controls. METHODS: We searched major electronic databases until December 2014 for studies reporting T2DM prevalence in patients with MDD. Two independent authors extracted data and completed methodological quality appraisal in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. A random effects meta-analysis was utilized. RESULTS: The initial electronic database search resulted in 145 valid hits and 16 publications with clearly defined MDD (n = 15,8834; 31% male; mean age = 39-78 years) met the eligibility criteria. The overall prevalence of T2DM was 8.7% (95% confidence interval [CI] = 7.3-10.2%). Mean age of the MDD sample predicted a higher prevalence of T2DM (β = 0.0411; 95% CI = 0.0032-0.079, P = .03; R² = .22). A comparative meta-analysis revealed people with MDD (n = 154,366) had a higher risk of T2DM versus general controls (n = 2,098,063; relative risk [RR] = 1.49; 95% CI = 1.29-1.72; P < 0.001, N = 10). The RR (N = 3) focusing on age- and gender-matched general population controls (n = 103,555) was 1.36 (95% CI = 1.28-1.44; P < 0.001, n [MDD] = 10,895). CONCLUSIONS: T2DM is significantly more common in people with MDD compared with the general population. The current meta-analysis indicates that action is needed in order to curb the diabetes epidemic in this high-risk population.
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Vancampfort et al. (2015) conducted a meta-analysis in Major depressive disorder (n=158,834). Major depressive disorder vs. General population controls was evaluated on Type 2 diabetes mellitus (T2DM) (RR 1.49, 95% CI 1.29-1.72, p=< 0.001). Major depressive disorder was associated with a higher risk of type 2 diabetes mellitus compared with general population controls (RR 1.49; 95% CI 1.29-1.72; P<0.001).
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