Key result
Rubella virus vaccination (HPV-77 DK 12 strain) was associated with joint symptoms in 2.8% of children, presenting as knee complaints (50%), carpal tunnel syndrome (33%), or polyarthritis (17%).
Why the study?
What are the clinical characteristics of acute arthritis complicating rubella vaccination in children?
Observational (n=40)
What are the clinical characteristics of acute arthritis complicating rubella vaccination in children?
Rubella vaccination with the HPV-77 DK 12 strain can be complicated by acute arthritis, predominantly affecting the knees or presenting as carpal tunnel syndrome, lasting an average of 18.4 days.
Raises awareness for post-vaccination joint symptoms in children; leaves open incidence, causality, and need for larger studies.
After a field trial of rubella virus vaccine (HPV‐77 DK 12 strain), 329 children (2.8%) developed joint symptoms. Forty had complete rheumatologic evaluation and constitute the basis of this report. Twenty children (50%) had predominantly knee complaints; 13 (33%) had symptoms suggesting the carpal tunnel syndrome; and 7 (17%) had polyarthritis. The mean duration of arthritis was 18.4 days, and the mean interval between vaccination and onset of arthritis was 30.6 days.
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Thompson et al. (1971) conducted an observational in Acute arthritis post-vaccination (n=40). Rubella virus vaccine (HPV-77 DK 12 strain) was evaluated on Development of joint symptoms. Rubella virus vaccination (HPV-77 DK 12 strain) was associated with joint symptoms in 2.8% of children, presenting as knee complaints (50%), carpal tunnel syndrome (33%), or polyarthritis (17%).
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