The first example of the transition‐metal‐catalyzed direct intermolecular C–H bond addition to ketones was achieved by using a rhodium catalyst. A significant influence of the directing group on the reactivity was observed, and sterically more hindered directing groups could promote the reaction. In addition, intermolecular hydrogen bonding played a role in stabilizing the product. The substrate scope for the quinoline derivatives was very good.
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Zhang et al. (2013) studied this question.
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