Key result
A 21% 30-day readmission rate in hospitalized HFpEF is linked to higher in-hospital mortality.
Why the study?
Rising numbers of patients have HFpEF, but due to poorly understood pathophysiology and a sparsity of studies, its management remains challenging.
Cohort (n=60,514)
Yes
In a nationwide US database, 21% of patients hospitalized for HFpEF were readmitted within 30 days, highlighting a significant healthcare burden often driven by cardio-renal syndrome.
BACKGROUND: There are rising numbers of patients who have heart failure with preserved ejection fraction (HFpEF). Poorly understood pathophysiology of heart failure with preserved and reduced ejection fraction and due to a sparsity of studies, the management of HFpEF is challenging. AIM: To determine the hospital readmission rate within 30 d of acute or acute on chronic heart failure with preserved ejection fraction and its effect on mortality and burden on health care in the United States. METHODS: We performed a retrospective study using the Agency for Health-care Research and Quality Health-care Cost and Utilization Project, Nationwide Readmissions Database for the year 2017. We collected data on hospital readmissions of 60514 adults hospitalized for acute or acute on chronic HFpEF. The primary outcome was the rate of all-cause readmission within 30 d of discharge. Secondary outcomes were cause of readmission, mortality rate in readmitted and index patients, length of stay, total hospitalization costs and charges. Independent risk factors for readmission were identified using Cox regression analysis. RESULTS: = 0.000). Our study showed that Medicaid insurance, higher Charlson co-morbidity score, patient admitted to a teaching hospital and longer hospital stay were significant variables associated with higher readmission rates. Lower readmission rate was found in residents of small metropolitan or micropolitan areas, older age, female gender, and private insurance or no insurance were associated with lower risk of readmission. CONCLUSION: We found that patients hospitalized for acute or acute on chronic HFpEF, the thirty day readmission rate was 21%. Readmission cases had a higher mortality rate and increased healthcare resource utilization. The most common cause of readmission was cardio-renal syndrome.
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Jha et al. (2022) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=60,514). Hospitalization for HFpEF was evaluated on All-cause readmission within 30 days of discharge. In patients hospitalized for acute or acute on chronic heart failure with preserved ejection fraction, the 30-day all-cause readmission rate was 21%, which was associated with higher in-hospital mortality.
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