Key result
A prior diagnosis of depression, but not PTSD, was associated with an increased risk of all-cause mortality over an average of 2 years (HR 1.17; 95% CI 1.06-1.28 for depression without PTSD).
Why the study?
Does a history of depression and/or PTSD increase all-cause mortality in primary care patients?
Cohort (n=35,715)
Yes
Does a history of depression and/or PTSD increase all-cause mortality in primary care patients?
Effect estimate: HR 1.17 (95% CI 1.06-1.28)
A prior diagnosis of depression, but not PTSD, is associated with an increased risk of all-cause mortality in veteran primary care patients over 2 years.
Supports monitoring depressed veterans in primary care; leaves open causality and PTSD effects pending trials.
OBJECTIVE: To determine whether a history of depression and/or posttraumatic stress disorder (PTSD) is associated with all-cause mortality in primary care patients over an average of 2 years. METHODS: Patients from seven Department of Veterans Affairs medical centers completed mailed questionnaires. Depression and PTSD status were determined from patient self-report of a prior diagnosis and/or electronic administrative data. Date of death was ascertained from Veterans Health Information Systems and Technology Architecture and the Department of Veterans Affairs' Beneficiary Identification and Records Locator System. RESULTS: Among 35,715 primary care patients, those with a history of depression without a history of PTSD (n = 6876) were at increased risk of death over an average of 2 years compared with patients with neither depression nor PTSD after adjustment for demographic variables, health behaviors, and medical comorbidity (hazard ratio (HR) = 1.17; 95% Confidence Interval (CI) = 1.06-1.28). However, patients with a history of PTSD without a history of depression (n = 748) were not at increased risk of death compared with patients with neither depression nor PTSD (HR = 0.84; 95% CI = 0.63-1.13). Patients with a history of both (n = 3762) were at increased risk of death after adjustment for demographic factors, although not after additional adjustment for health behaviors and medical comorbidity (HR = 0.90; 95% CI = 0.78-1.04). CONCLUSIONS: In a large sample of veterans, a prior diagnosis of depression, but not PTSD, was associated with an increased risk of death over an average of 2 years after adjusting for age, demographic variables, health behaviors, and medical comorbidity.
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Kinder et al. (2007) conducted a cohort in Depression and Posttraumatic Stress Disorder (n=35,715). History of depression without PTSD vs. Neither depression nor PTSD was evaluated on All-cause mortality (HR 1.17, 95% CI 1.06-1.28). A prior diagnosis of depression, but not PTSD, was associated with an increased risk of all-cause mortality over an average of 2 years (HR 1.17; 95% CI 1.06-1.28 for depression without PTSD).
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