Key result
Filling the drug-binding pocket of human rhinovirus 14 with bulky side chains did not impair the viral life cycle, indicating that the cavity itself, not putative pocket factors, is crucial for infection.
The drug-binding cavity itself, rather than putative pocket factors, is crucial for rhinovirus capsid dynamics and infection.
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Hypothesis-generating for cavity-targeted rhinovirus antivirals; leaves open translation beyond animal models.
Katpally et al. (2007) studied Human Rhinovirus. WIN drug-binding pocket mutagenesis vs. Wild-type virus was evaluated on Viral infectivity and capsid dynamics. Filling the drug-binding pocket of human rhinovirus 14 with bulky side chains did not impair the viral life cycle, indicating that the cavity itself, not putative pocket factors, is crucial for infection.
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