Key result
Uncoating of human rhinovirus serotype 2 occurs in intact late endosomes at pH 5.5, a process requiring ATP and prevented by the V-ATPase inhibitor bafilomycin A1.
HRV2 uncoating occurs in intact late endosomes at an acidic pH of 5.5, independent of direct receptor involvement.
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May guide endosome-targeted antivirals; leaves open translation from animal models to human disease.
Prchla et al. (1994) studied Human rhinovirus serotype 2 infection (in vitro). Bafilomycin A1 was evaluated on Capsid modification and uncoating mechanism. Uncoating of human rhinovirus serotype 2 occurs in intact late endosomes at pH 5.5, a process requiring ATP and prevented by the V-ATPase inhibitor bafilomycin A1.
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