Long-Term Excess Mortality in Takotsubo Cardiomyopathy: Predictors, Causes and Clinical Consequences
Key result
Takotsubo cardiomyopathy is linked to ~58% higher long-term mortality than matched STEMI.
- HR 1.58
- 95% CI 1.07-2.33
- P=0.02
- n=572
Why the study?
Does takotsubo cardiomyopathy increase long-term mortality compared to STEMI in matched patients?
Population
286 patients with takotsubo cardiomyopathy matched for age and gender with 286 patients presenting with…
Comparison
Takotsubo cardiomyopathy (TTC) vs ST-segment elevation myocardial infarction (STEMI)
Design
Cohort
Follow-up
mean 3.8 ± 2.5 years
Authors
Discussion
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Implication
Takotsubo cardiomyopathy may warrant intensified long-term surveillance versus STEMI; observational data leaves open causality and targeted interventions.
Study Design
Type
Cohort (n=572)
Structured PICO
Does takotsubo cardiomyopathy increase long-term mortality compared to STEMI in matched patients?
P
Population
286 patients with takotsubo cardiomyopathy (TTC) matched for age and gender with 286 patients presenting with ST-segment elevation myocardial infarction (STEMI) (total n=572).
I
Intervention
Takotsubo cardiomyopathy (TTC)
C
Comparator
ST-segment elevation myocardial infarction (STEMI)
O
Outcome
Long-term mortalityhard clinical
Main Result
Effect estimate: HR 1.58 (95% CI 1.07-2.33)
Absolute Event Rate: 24.7% vs 15.1%
p-value: p=0.02
Long-term mortality in takotsubo cardiomyopathy patients is higher than previously expected and exceeds that of age- and gender-matched STEMI patients.
Cite This Study
Stiermaier et al. (2016) conducted a cohort in Takotsubo cardiomyopathy (n=572). Takotsubo cardiomyopathy vs. ST-segment elevation myocardial infarction (STEMI) was evaluated on long-term mortality (HR 1.58, 95% CI 1.07-2.33, p=0.02). Takotsubo cardiomyopathy was associated with significantly higher long-term mortality compared with a matched STEMI cohort (24.7% vs. 15.1%, HR 1.58; 95% CI 1.07-2.33; P=0.02).