Key result
Pulsed-field ablation for persistent AF achieves ~66% one-year survival free from atrial tachyarrhythmia.
Why the study?
Pulsed-field ablation is a novel nonthermal approach, but its feasibility and safety for persistent AF required investigation.
Is pulsed-field ablation (PFA) feasible, safe, and effective at preventing atrial tachyarrhythmia recurrence in patients with persistent atrial fibrillation?
Cohort (n=32)
Is pulsed-field ablation (PFA) feasible, safe, and effective at preventing atrial tachyarrhythmia recurrence in patients with persistent atrial fibrillation?
Pulsed-field ablation utilizing an extensive lesion set (PVI, LAPW, CTI, and MI block) is feasible and safe for persistent atrial fibrillation, achieving a 65.6% 1-year freedom from arrhythmia.
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Supports PFA feasibility with extensive lesions in persistent AF; leaves open efficacy versus thermal ablation in randomized trials.
Chen et al. (2025) conducted a cohort in Persistent atrial fibrillation (PeAF) (n=32). Pulsed-field ablation (PFA) was evaluated on One-year survival free from atrial tachyarrhythmia post-ablation. Pulsed-field ablation for persistent atrial fibrillation achieved a 65.6% rate of 1-year survival free from atrial tachyarrhythmia, with 100% acute success for pulmonary vein isolation.
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