Key result
Left ventricular reverse remodeling (≥9.5% reduction in LVESV) after CRT was associated with significantly lower all-cause mortality compared to nonresponders (6.9% vs 30.6%, P=0.0003).
Why the study?
Does left ventricular reverse remodeling after cardiac resynchronization therapy predict long-term survival and heart failure events in patients with advanced heart failure?
Population
141 patients with advanced heart failure and dilated cardiomyopathy, mean age 64+/-11 years, 73% men.
Comparison
Cardiac resynchronization therapy with… vs Patients without significant left ventricular…
Design
Cohort
Follow-up
mean 695+/-491 days
Authors
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May aid post-CRT risk stratification in advanced HF; leaves open whether targeting remodeling improves outcomes.
Cohort (n=141)
Does left ventricular reverse remodeling after cardiac resynchronization therapy predict long-term survival and heart failure events in patients with advanced heart failure?
Absolute Event Rate: 6.9% vs 30.6%
p-value: p=0.0003
A reduction in left ventricular end-systolic volume of ≥9.5% at 3-6 months after CRT is a strong predictor of lower long-term mortality and heart failure events, whereas clinical parameters are not.
Yu et al. (2005) conducted a cohort in advanced heart failure (n=141). Left ventricular reverse remodeling (≥9.5% reduction in LVESV) vs. Nonresponders (<9.5% reduction in LVESV) was evaluated on all-cause mortality (p=0.0003). Left ventricular reverse remodeling (≥9.5% reduction in LVESV) after CRT was associated with significantly lower all-cause mortality compared to nonresponders (6.9% vs 30.6%, P=0.0003).
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