Sensitive Cardiac Troponin T Assay and the Risk of Incident Cardiovascular Disease in Women With and Without Diabetes Mellitus
Why the study?
Does detectable high-sensitivity cardiac troponin T predict incident cardiovascular disease in women with and without diabetes mellitus?
Population
Women without baseline cardiovascular disease from the Women's Health Study, including a cohort of 512…
Comparison
Detectable high-sensitivity cardiac troponin T vs Undetectable high-sensitivity cardiac troponin T
Design
Cohort
Follow-up
median 12.3 years
Authors
Discussion
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Member takes
Implication
May inform CVD risk stratification in diabetic women; leaves open utility and generalizability pending prospective validation.
Structured PICO
Does detectable high-sensitivity cardiac troponin T predict incident cardiovascular disease in women with and without diabetes mellitus?
P
Population
Women without baseline cardiovascular disease from the Women's Health Study, including a cohort of 512 diabetic women and a case-cohort sample of nondiabetic women (n=564 subcohort, 479 events).
I
Intervention
Detectable high-sensitivity cardiac troponin T (≥ 0.003 μg/L)
C
Comparator
Undetectable high-sensitivity cardiac troponin T (< 0.003 μg/L)
O
Outcome
Incident cardiovascular disease (composite of myocardial infarction, stroke, cardiovascular death) at median 12.3 years follow-upcomposite
Very low but detectable levels of high-sensitivity cardiac troponin T are an independent predictor of incident cardiovascular events and cardiovascular death in women with diabetes, but not in healthy nondiabetic women.
Cite This Study
Everett et al. (2011) studied this question.