Key result
Irbesartan significantly reduced QTc dispersion by a mean of 11.4 ms (P=0.02) in elderly hypertensive subjects, whereas the 9.7 ms reduction with amlodipine did not reach statistical significance.
Why the study?
Does irbesartan reduce QT dispersion compared to amlodipine in elderly subjects with mild to moderate hypertension?
RCT (n=188)
Double-blind
parallel group
Yes
Does irbesartan reduce QT dispersion compared to amlodipine in elderly subjects with mild to moderate hypertension?
Absolute Event Rate: -11.4% vs -9.7%
Irbesartan significantly improves QT dispersion in elderly hypertensive patients compared to amlodipine, potentially offering benefits in preventing sudden cardiac death.
No takes yet. Share an insight, caveat, or question.
Irbesartan may be preferred over amlodipine to improve QTc dispersion in elderly hypertension; extends ARB effects on repolarization beyond BP reduction.
Lim et al. (1999) conducted an RCT in mild to moderate hypertension (n=188). irbesartan vs. amlodipine was evaluated on Change in QTc dispersion. Irbesartan significantly reduced QTc dispersion by a mean of 11.4 ms (P=0.02) in elderly hypertensive subjects, whereas the 9.7 ms reduction with amlodipine did not reach statistical significance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: