Key result
Force-length area is closely correlated with oxygen consumption (r = 0.94-0.98) in ferret papillary muscle, independent of the mode of contraction.
Population
Ferret papillary muscle preparation
Comparison
Examination of force-length area under a wide… vs Other mechanical indexes such as peak force and…
Design
Preclinical
Authors
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Caution against clinical adoption from animal data; leaves open validation in intact human hearts.
Effect estimate: r = 0.94-0.98
Force-length area correlates closely with oxygen consumption in ferret papillary muscle, suggesting it may be the best mechanical index for calculating regional oxygen consumption, though the time-varying elastance model may not fully describe cardiac muscle energetics during isometric contraction.
Hisano et al. (1987) studied Cardiac muscle energetics. Force-length area measurement vs. Peak force and force-time integral was evaluated on Correlation with oxygen consumption (r = 0.94-0.98). Force-length area is closely correlated with oxygen consumption (r = 0.94-0.98) in ferret papillary muscle, independent of the mode of contraction.
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