Key result
Targeting the ACE2/Ang-1-7/MasR axis shows preclinical promise for preventing and treating aortic aneurysm.
Why the study?
Aortic aneurysm has a high mortality rate with no effective medical treatments beyond surgery, and products targeting the protective Ang-(1-7)/MasR pathway still lack clinical validation.
Targeting the Ang-(1-7)/MasR pathway offers a promising new therapeutic strategy for the prevention and treatment of aortic aneurysms, highlighting the need for future clinical validation.
Answers are grounded in this paper and cite their sources.
Does not support clinical use in aortic aneurysm; leaves open hypothesis for targeted trials.
Aortic aneurysm (AA) is an aortic disease with a high mortality rate, and other than surgery no effective preventive or therapeutic treatment have been developed. The renin-angiotensin system (RAS) is an important endocrine system that regulates vascular health. The ACE2/Ang-(1-7)/MasR axis can antagonize the adverse effects of the activation of the ACE/Ang II/AT1R axis on vascular dysfunction, atherosclerosis, and the development of aneurysms, thus providing an important therapeutic target for the prevention and treatment of AA. However, products targeting the Ang-(1-7)/MasR pathway still lack clinical validation. This review will outline the epidemiology of AA, including thoracic, abdominal, and thoracoabdominal AA, as well as current diagnostic and treatment strategies. Due to the highest incidence and most extensive research on abdominal AA (AAA), we will focus on AAA to explain the role of the RAS in its development, the protective function of Ang-(1-7)/MasR, and the mechanisms involved. We will also describe the roles of agonists and antagonists, suggest improvements in engineering and drug delivery, and provide evidence for Ang-(1-7)/MasR's clinical potential, discussing risks and solutions for clinical use. This study will enhance our understanding of AA and offer new possibilities and promising targets for therapeutic intervention.
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Yang et al. (2024) conducted a review in Aortic aneurysm. ACE2/Ang-(1-7)/MasR axis targeting was evaluated. Targeting the ACE2/Ang-(1-7)/MasR axis offers a promising therapeutic strategy for the prevention and treatment of aortic aneurysm, though clinical validation is currently lacking.
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