Key result
≥2 risk factors linked to ~12-fold higher odds of appropriate ICD shocks in pediatric HCM.
Why the study?
Identifying children with HCM at high risk of sudden cardiac death who require an ICD for primary prevention remains a crucial clinical issue.
Do implantable cardioverter-defibrillators effectively prevent sudden cardiac death in children with hypertrophic cardiomyopathy?
Population
77 children and adolescents with HCM undergoing ICD implantation for primary prevention
Design
Single-center observational cohort study
Authors
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Supports ICD use in high-risk pediatric HCM; leaves open randomized confirmation of sudden death prevention.
Cohort (n=200)
No
Do implantable cardioverter-defibrillators effectively prevent sudden cardiac death in children with hypertrophic cardiomyopathy?
ICDs provide effective primary prevention of sudden cardiac death in pediatric hypertrophic cardiomyopathy, with appropriate shocks strongly correlating with the presence of multiple risk factors and specific 5-year risk thresholds.
Leontyeva et al. (2025) conducted a cohort in Hypertrophic cardiomyopathy (n=200). Implantable cardioverter-defibrillators (ICDs) was evaluated on Appropriate shocks on ventricular tachycardia and ventricular fibrillation. ICDs delivered appropriate shocks in 10.4% of children with hypertrophic cardiomyopathy, with a higher likelihood in those with ≥2 risk factors (OR 12.12; 95% CI 1.47-99.65).
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