Key result
Conservative HOCM treatment linked to ~10-fold higher SCD risk versus invasive therapy.
Why the study?
There is no clear consensus on the long-term effects of conservative versus invasive treatment strategies in patients with hypertrophic obstructive cardiomyopathy.
Does invasive treatment reduce mortality and SCD-related events compared to conservative treatment in patients with HOCM?
Population
106 HOCM patients
Comparison
Conservative treatment vs alcohol septal ablation vs myectomy
Design
Retrospective cohort study
Follow-up
Mean 7.7 ± 4.9 years
Authors
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May favor invasive HOCM strategies to lower SCD events; leaves open confirmation in randomized trials before practice change.
Cohort (n=106)
No
Does invasive treatment reduce mortality and SCD-related events compared to conservative treatment in patients with HOCM?
Effect estimate: HR 10.66 (95% CI 1.88-60.55)
p-value: p=0.034
Invasive treatment for HOCM is associated with a lower risk of SCD-related events compared to conservative management, though overall survival is similar and invasive treatment increases the need for pacing.
Hoedemakers et al. (2018) conducted a cohort in hypertrophic obstructive cardiomyopathy (HOCM) (n=106). Conservative treatment vs. Invasive treatment (alcohol septal ablation and myectomy) was evaluated on Sudden cardiac death (SCD)-related events (HR 10.66, 95% CI 1.88-60.55, p=0.034). Conservative treatment in patients with HOCM was associated with a significantly higher risk of SCD-related events compared to invasive treatment (HR 10.66; 95% CI 1.88-60.55).
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