Key result
Mutation-specific risk stratification in hypertrophic cardiomyopathy is not clinically useful for predicting prognosis due to contradictory phenotypes and multi-factorial disease expression.
Why the study?
Does mutation type predict prognosis in hypertrophic cardiomyopathy?
Does mutation type predict prognosis in hypertrophic cardiomyopathy?
Mutation-specific risk stratification in hypertrophic cardiomyopathy is not currently clinically useful for predicting prognosis.
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Mutation-specific stratification should not guide HCM prognosis; leaves open multi-factorial models incorporating modifiers.
Landstrom et al. (2010) conducted a review in Hypertrophic cardiomyopathy (HCM). Mutation-specific risk stratification was evaluated. Mutation-specific risk stratification in hypertrophic cardiomyopathy is not clinically useful for predicting prognosis due to contradictory phenotypes and multi-factorial disease expression.
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