Key result
Comorbidities, low MET, and preoperative frailty are linked to adverse frailty trajectories after gastrointestinal surgery.
Why the study?
Frailty is a dynamic process, but its changes following surgery remain unclear.
Observational (n=212)
Frailty is a dynamic process after gastrointestinal tumor surgery, and older patients with specific risk factors (e.g., more comorbidities, low MET/6MWT, preoperative frailty) are prone to remain in or transition to frailty, highlighting the need for targeted rehabilitation.
May support frailty monitoring to stratify risk in older GI surgery patients; hypothesis-generating for targeted rehabilitation trials.
BACKGROUND: Frailty is a dynamic process, but its changes following surgery are unclear. This study aimed to investigate frailty change trajectories and their risk factors in older patients undergoing gastrointestinal tumor surgery. METHODS: The Frail Scale (FS) assessed frailty from preoperative to 180 days after surgery. The latent class analysis (LCA) was established to identify the most fitting latent class, and the risk factors of these change trajectories were analyzed. We also recorded and explored changes in FS components. RESULTS: 212 elderly patients (aged ≥ 60 years) scheduled for gastrointestinal tumor surgery under general anesthesia completed the study. The LCA identified four optimal trajectory groups. There are differences in gender, age, marriage, American Society of Anesthesiologists (ASA) classification, number of comorbidities, hemoglobin, Charlson comorbidity index (CCI), the six-minute walk test (6MWT), metabolic equivalent (MET), preoperative frailty status, and time to first ambulation among the four groups (P < 0.05). Comorbidities, MET, preoperative frailty, age, first time to ambulation, and 6WMT were independent factors influencing abnormal frailty trajectories. Overall, the FS components all changed 180 days after the surgery. Except for weight loss, the changes in the other components were related to the surgical site (P < 0.05). CONCLUSION: Frailty is a dynamic process. Older patients with more comorbidities, low MET and 6WMT, preoperative frailty, and later time to ambulation are prone to remain in frailty or transition to it after surgery. Clinical attention and targeted rehabilitation should be provided to them.
No takes yet. Share an insight, caveat, or question.
You et al. (2025) conducted an observational in gastrointestinal tumor (n=212). Gastrointestinal tumor surgery was evaluated on Frailty change trajectories assessed by the Frail Scale. In 212 older patients undergoing gastrointestinal tumor surgery, four frailty change trajectories were identified, with comorbidities, low MET, and preoperative frailty as independent risk factors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: