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February 19, 2018Canadian Medical Association JournalOpen Access

Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study

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Key result

Preadmission frailty independently and dose-dependently predicted 6-month readmission or death in older emergency abdominal surgery patients, with frail patients having an adjusted OR of 3.27 compared to well patients.

Why the study?

Does frailty increase the risk of readmission or death in older patients undergoing emergency abdominal surgery?

Population

308 patients aged ≥65 years who underwent emergency abdominal surgery at 2 tertiary care centres and needed…

Comparison

Vulnerable or Frail status vs Well status (Clinical Frailty Scale score 1-2)

Design

Cohort

Follow-up

6 months

Authors

YLYibo LiUniversity of Chinese Academy of SciencesJPJenelle L. PedersonUniversity of AlbertaTCThomas A. ChurchillUniversity of Alberta

Discussion

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Implication

Frailty assessment identifies older emergency surgery patients at elevated 30-day readmission/death risk; leaves open whether targeted interventions improve outcomes.

Study Design

Type

Cohort (n=308)

Multicenter

Yes

Structured PICO

Does frailty increase the risk of readmission or death in older patients undergoing emergency abdominal surgery?

P
Population
308 older adults (median age 75, 45.4% female) who survived emergency abdominal surgery and required assistance with fewer than 3 activities of daily living, followed for 6 months.
E
Exposure
Vulnerable (Clinical Frailty Scale score 3-4) or Frail (score 5-6) status
C
Comparator
Well status (Clinical Frailty Scale score 1-2)
O
Outcome
Composite of 30-day and 6-month all-cause readmission or deathcomposite

Main Result

Odds Ratio: 3.27 (95% CI 1.32–8.12)

Absolute Event Rate: 54.4% vs 15.3%

p-value: p=<0.001

Frailty is highly prevalent in older patients undergoing emergency abdominal surgery and independently predicts a higher risk of readmission or death up to 6 months post-discharge.

Limitations

  • Findings cannot be generalized to severely frail or terminally ill patients because these groups were excluded.
  • Did not compare different tools or assess more objective frailty measures.
  • Did not assess long-term disability or quality of life.
  • 30-day results may have been limited by lower event rates.

Cite This Study

Li et al. (2018) conducted a cohort in Emergency abdominal surgery in older adults (n=308). Preadmission frailty vs. Well patients (Clinical Frailty Scale score 1-2) was evaluated on Composite all-cause readmission or death at 6 months (OR 3.27, 95% CI 1.32-8.12, p=<0.001). Preadmission frailty independently and dose-dependently predicted 6-month readmission or death in older emergency abdominal surgery patients, with frail patients having an adjusted OR of 3.27 compared to well patients.

synapsesocial.com/papers/6a61cc88f2fc5dc74fc1f5a3https://doi.org/10.1503/cmaj.161403
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Frailty as a Predictor of Surgical Outcomes in Older Patients2010 · 2,210 citations
  2. 2Association between frailty and 30-day outcomes after discharge from hospital2015 · 247 citations
  3. 3Are the frail destined to fail? Frailty index as predictor of surgical morbidity and mortality in the elderly2012 · 539 citations
  4. 4A global clinical measure of fitness and frailty in elderly people2005 · 9,255 citations
  5. 5Immunologic Changes in Frail Older Adults2014 · 39 citations