Long-term Response to Electrochemotherapy as Sole Treatment in a Cat with Metastatic Lower Eyelid Mast Cell Tumor

Mast cell tumors (MCT) in anatomically complex periocular regions of cats often preclude curative surgery. Electrochemotherapy (ECT) offers local control while preserving function. A 17-year-old spayed domestic shorthair presented with a 2.5 cm lower eyelid MCT and ipsilateral submandibular lymph node metastasis confirmed histologically. Two ECT sessions, three weeks apart, were performed using bleomycin (first intratumoral, second combined intratumoral and intravenous). The protocol was well tolerated, without local or systemic toxicities. Complete remission was achieved within six weeks after the second session and has been maintained for three years with 6-monthly rechecks. ECT provided durable control without ocular morbidity and represents a viable alternative when surgery is not feasible. This case supports ECT as sole therapy for feline cutaneous MCT in challenging locations and justifies further prospective evaluation.