Multifunctional nanoplatforms combining magnetic response, luminescence, and drug-loading capability are highly desirable for precise diagnostic and therapeutic applications. Here, magneto-luminescent nanocomposites based on neodymium-doped oxide and fluoride hosts were synthesized via a reproducible mesoporous silica co-encapsulation strategy. YAG:Nd and LaF 3 :Nd nanophosphors were co-encapsulated with superparamagnetic iron oxide nanoparticles (SPIONs), forming core–shell nanocomposites with preserved crystalline phases and effective magnetic integration. After mesoporous silica coating, nanoparticles exhibited improved monodispersity and suspension stability. Both systems showed characteristic Nd 3+ emissions in NIR-I and NIR-II windows under 808 nm excitation with retained peak positions. The nanocomposites demonstrated near-superparamagnetic behavior and magnetic hyperthermia performance. Mesoporous structures enabled indocyanine green loading with sustained first-order release and good cytocompatibility in MDA-MB-231 cells. The strategy was validated using Tb 3+ :LaF 3 , retaining green emission after co-encapsulation, demonstrating a reproducible multifunctional theranostic platform.
Sengar et al. (Fri,) studied this question.