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May 18, 2026Matrix Biology Plus0 citationsOpen Access

Ageing Affects Extracellular Matrix Turnover and Remodeling in the Kidney

Ageing impacts extracellular matrix turnover and remodelling in the kidney

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Authors

RPRebecca PrestonAHAnna HoyleAHAlana Stevenson Harris

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Overview

Quantitative analysis reveals age-related changes in matrix protein turnover in the kidney, indicating impaired degradation leads to fibrosis.

Key Points

  • To analyze how ageing impacts the turnover and remodeling of the extracellular matrix in the kidney across different life stages.
  • Conducted a quantitative analysis of kidney matrix protein turnover using 13C-lysine metabolic labeling in healthy mice at 8, 22, 52, and 78 weeks of age.
  • Measured half-lives of various collagen types and assessed matrix structural changes with peptide location fingerprinting.
  • Collagen IV half-lives increased from weeks in young kidneys to years in aged kidneys, indicating reduced renewal capacity.
  • Age-related fibrosis was linked to impaired degradation rather than increased synthesis of matrix proteins.
  • Structural changes in collagen VI and altered protease accessibility were identified, contributing to renal remodeling.
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Cite This Study

Preston et al. (2026) studied this question.

synapsesocial.com/papers/6a0aac6d5ba8ef6d83b6fddahttps://doi.org/10.1016/j.mbplus.2026.100197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling2015 · 277 citations
  2. 2Circadian and permanent pools of extracellular matrix co-exist in tendon tissue, but have distinct rates of turnover and differential responses to ageing2024 · 1 citations
  3. 3The Role of Collagen VIII in the Aging Mouse Kidney2024
  4. 4Macrophage regulation of extracellular matrix remodeling in aging skeletal muscle2026
  5. 5Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: Collagen accumulation in the young and loss in the aged2012 · 107 citations