What does this research mean for the field?

In cancer patients with neutropenic bacteremia treated with appropriate antibiotics, the severity of neutropenia (profound versus severe) is not associated with 30-day mortality. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine if the severity of neutropenia impacts 30-day mortality in bacteremic patients with cancer.

May 18, 2026BMC Infectious DiseasesOpen Access

Does the severity of neutropenia affect mortality in bacteremic cancer patients?

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Authors

PCPeng-Hao ChangChang Gung University PHPo-Yen HuangNational Tsing Hua University SSShian-Sen ShieChang Gung University

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Implication

Retrospective cohort study analyzes neutropenia severity effects on mortality in cancer patients, suggesting manageable risks with antibiotics.

Key Points

To determine if the severity of neutropenia impacts 30-day mortality in bacteremic patients with cancer.
Retrospective cohort study of adults with neutropenic bacteremia receiving cefepime for over 48 hours
Included patients with severe (ANC 100–500 cells/µL) and profound neutropenia (ANC < 100 cells/µL)
Used Cox proportional hazards model to identify predictors of mortality.
Overall mortality rate was 13.5% in 200 bacteremias
No significant mortality difference between profound (20.0%) and severe neutropenia groups (11.3%; P = 0.121)
Major mortality predictors included pneumonia (aHR 3.81), higher Pitt scores (aHR 1.26 per point), and Charlson index (aHR 1.27 per point).

Cite This Study

Chang et al. (2026) studied this question.

synapsesocial.com/papers/6a0aacb35ba8ef6d83b7015f https://doi.org/10.1186/s12879-026-13574-2

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Implication

Retrospective cohort study analyzes neutropenia severity effects on mortality in cancer patients, suggesting manageable risks with antibiotics.

Does the severity of neutropenia affect mortality in bacteremic cancer patients?

Discussion

Member takes

Implication

Key Points

Cite This Study

Does the severity of neutropenia affect mortality in bacteremic cancer patients?

Discussion

Member takes

Implication

Key Points

Cite This Study

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