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This research aims to explore how genetic screens in C. elegans have enhanced our understanding of innate immunity mechanisms.

May 18, 2026HeredityOpen Access

Worming out defence strategies: mechanisms of immunity through the lens of genetic screens in C. elegans

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This research aims to explore how genetic screens in C. elegans have enhanced our understanding of innate immunity mechanisms.
Utilized mutagenesis-based screens and RNAi functional genomics in C. elegans.
Compared immune responses to a variety of pathogens including bacteria, viruses, and eukaryotic pathogens.
Investigated signalling pathways and cross-tissue immune communication involving neurons, intestine, and epidermis.
Discovered evolutionarily conserved pathways and species-specific immunity mechanisms.
Identified mediators of pathogen recognition and cellular surveillance mechanisms.
Highlighted the role of cross-tissue communication in regulating immune responses.

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Genetic screens reveal innate immunity mechanisms in C. elegans, indicating pathways and tissue communication involved in defense.

Grover et al. (2026) studied this question.

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