Key result
Kan-Li co-activation metric strongly discriminates meditation from focus states and classifies allosteric proteins.
The Kan-Li co-activation framework and Zhongtian operator provide a theoretical cross-scale metric for integrative capacity from proteins to whole-brain networks.
Hypothesis-generating for integrative capacity signatures; leaves open clinical translation in consciousness research.
We propose Kan-Li co-activation as a scale-invariant geometric signature of integrative capacity, with three converging lines of evidence: (1) Molecular — ZT_potential ranks #1 in RF importance for allosteric classification (AUC 0.913, d=-0.894, p<0.001, n=569). (2) EEG — HT-alphaSI discriminates meditation vs. focus with d=1.51, p=3e-14 (n=50). (3) Connectome — HCP 400-ROI Limbic-DMN co-activation hierarchy: meditation > wakefulness > propofol anesthesia. The Zhongtian operator (E_ZT=40) serves as the harmonic bridge across all scales. Cross-scale neuroreceptor ZT_potential (8 PDB structures) confirms functional flexibility hierarchy. Framework complements IIT (Tononi 2004) and GWT (Baars 1988).
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Yao-Kai Kao (2026) studied Consciousness. Kan-Li co-activation metric vs. Focus / Wakefulness / Propofol anesthesia was evaluated on Discrimination of meditation vs. focus (d=1.51, p=3e-14). The Kan-Li co-activation metric successfully discriminated meditation from focus states (d=1.51, p=3e-14) and classified allosteric proteins (AUC 0.913, p<0.001).
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