Formulation and Evaluation of Rutin Trihydrate Topical Hydrogel

Rutin, a naturally occurring flavonoid, has powerful anti-inflammatory, antioxidant, and vascular-protective effects, however it is poorly soluble in water and has low oral bioavailability. The current work sought to develop, optimise, and assess a topical hydrogel system containing rutin trihydrate to improve skin delivery and local therapeutic efficacy. Hydrogels were made with Carbopol 934 as a gelling agent and Transcutol-P as a cosolvent and permeation enhancer. UV calibration, solubility determination, and drug-excipient compatibility tests were all performed prior to formulation.Hydrogel batches were tested for physical appearance, spreadability, pH, viscosity, drug content, and in vitro release profile using Franz diffusion cells. The optimised hydrogel demonstrated desirable rheological qualities, good spreadability, pH within the skin-compatible range, high drug content, and improved release characteristics. In this study byusing Transcutol P and Carbopol 934, a topical hydrogel of rutin trihydrate will be created.Its viscosity, rheology, stability, and suitability for topical administration will all be assessed. By examining drug penetration through skin at various enhancer doses, it further explores Transcutol P's function as a skin-permeation enhancer.