The Intersection of Inflammatory Skin Diseases and Women’s Reproductive Health: Challenges in Managing Psoriasis and Atopic Dermatitis During Pregnancy and Hormonal Fluctuations

Aim To explore the impact of psoriasis and atopic dermatitis (AD) on women’s reproductive health, focusing on fertility, pregnancy, and treatment considerations during hormonal fluctuations. Methods We reviewed current evidence from clinical and immunological studies on reproductive‐aged women with psoriasis and AD, emphasizing fertility outcomes, pregnancy course, and therapeutic safety. Results Psoriasis may affect fertility through comorbidities, chronic inflammation, and reduced ovarian reserve or sexual activity. During pregnancy, many women experience improvement in psoriasis, although moderate‐to‐severe cases remain at risk for complications, with limited safe treatment options due to uncertain drug safety profiles. In contrast, AD frequently worsens during pregnancy because of hormone‐driven immune shifts, creating a demand for safe and effective therapies. Conclusions Psoriasis and AD present distinct challenges for women during their reproductive years. Understanding immunological changes and developing tailored management strategies are crucial for optimizing outcomes in fertility and pregnancy.