What question did this study set out to answer?

To evaluate longitudinal changes in prostate-specific antigen (PSA) levels over decades in men with and without benign or malignant prostate disease.

April 22, 1992JAMA

Longitudinal Evaluation of Prostate-Specific Antigen Levels in Men With and Without Prostate Disease

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Authors

HCH. Ballentine CarterJohns Hopkins University

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Implication

Case-control study shows accelerated PSA increases years before prostate cancer diagnosis in aging men, indicating PSA rate of change acts as an early disease marker.

Key Points

To evaluate longitudinal changes in prostate-specific antigen (PSA) levels over decades in men with and without benign or malignant prostate disease.
Nested case-control study within the Baltimore Longitudinal Study of Aging evaluating 54 men: 16 healthy controls, 20 with benign prostatic hyperplasia (BPH), and 18 with prostate cancer.
Serum PSA and androgen levels were measured in banked serum samples collected between 7 and 25 years prior to histologic diagnosis or exclusion of disease.
Age-adjusted rates of PSA change differed significantly across cohorts (prostate cancer > BPH > controls; P < .01), whereas androgen trajectories did not differ and control PSA levels remained stable with age.
At 5 years pre-diagnosis, when absolute PSA levels were indistinguishable between cancer and BPH, PSA rate of change was 0.75 µg/L per year in cancer cases, distinguishing cancer from BPH with 90% specificity and from controls with 100% specificity.

Cite This Study

H. Ballentine Carter (1992) studied this question.

synapsesocial.com/papers/6a0ab41b48609dcc0aac9887 https://doi.org/10.1001/jama.1992.03480160073037

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Implication

Case-control study shows accelerated PSA increases years before prostate cancer diagnosis in aging men, indicating PSA rate of change acts as an early disease marker.

Longitudinal Evaluation of Prostate-Specific Antigen Levels in Men With and Without Prostate Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Longitudinal Evaluation of Prostate-Specific Antigen Levels in Men With and Without Prostate Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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