Key result
Previous adverse cardiac events linked to ~440% higher SCD risk in childhood HCM.
Why the study?
Do specific clinical risk factors predict sudden cardiac death or cardiovascular death in childhood hypertrophic cardiomyopathy?
Population
3,394 patients under 18 years of age with childhood hypertrophic cardiomyopathy (pooled from 25 studies)
Comparison
Presence of clinical risk factors vs Absence of these clinical risk factors
Design
Meta-analysis
Authors
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Prior adverse events and NSVT warrant inclusion in pediatric HCM SCD risk models; extends adult data but leaves optimal thresholds open.
Meta-Analysis (n=3,394)
Do specific clinical risk factors predict sudden cardiac death or cardiovascular death in childhood hypertrophic cardiomyopathy?
Effect estimate: HR 5.4 (95% CI 3.67-7.95)
p-value: p=<0.001
Previous adverse cardiac events and non-sustained ventricular tachycardia are significant predictors of sudden cardiac death in childhood hypertrophic cardiomyopathy, though the overall evidence base remains limited.
Norrish et al. (2017) conducted a meta-analysis in Childhood hypertrophic cardiomyopathy (n=3,394). Clinical risk factors (e.g., previous adverse cardiac event, non-sustained ventricular tachycardia) was evaluated on Sudden cardiac death (SCD), SCD-equivalent events, or cardiovascular death (CVD) (HR 5.4, 95% CI 3.67-7.95, p=<0.001). Previous adverse cardiac events (HR 5.4; 95% CI 3.67-7.95; p<0.001) and non-sustained ventricular tachycardia (HR 2.13) significantly increased the risk of sudden cardiac death in childhood HCM.
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