Key result
In patients with hypertrophic cardiomyopathy, moderate or severe myocardial fibrosis was associated with significantly reduced peak left atrial strain (-0.2% vs 17.9%, P<0.001).
Why the study?
Is myocardial fibrosis associated with left atrial and ventricular dysfunction in patients with hypertrophic cardiomyopathy?
Population
30 consecutive patients with hypertrophic cardiomyopathy, mean age 49.7 +/- 10.4 years, 20 males, mean NYHA…
Comparison
Presence of moderate or severe myocardial… vs No myocardial fibrosis
Design
Cross-sectional
Authors
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Supports multimodality imaging for HCM dysfunction assessment; leaves open longitudinal validation of prognostic utility.
Observational (n=30)
Is myocardial fibrosis associated with left atrial and ventricular dysfunction in patients with hypertrophic cardiomyopathy?
Absolute Event Rate: -0.2% vs 17.9%
p-value: p=<0.001
In patients with hypertrophic cardiomyopathy, the presence of myocardial fibrosis on MRI is strongly associated with both left ventricular and left atrial dysfunction on speckle-tracking echocardiography, as well as worse heart failure symptoms.
Prinz et al. (2012) conducted an observational in Hypertrophic cardiomyopathy (n=30). Moderate or severe myocardial fibrosis vs. No myocardial fibrosis was evaluated on Peak left atrial strain (epsilon) (p=<0.001). In patients with hypertrophic cardiomyopathy, moderate or severe myocardial fibrosis was associated with significantly reduced peak left atrial strain (-0.2% vs 17.9%, P<0.001).
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