Key result
Combined Modified Alvarado and ultrasound scoring yields ~88% diagnostic accuracy for acute appendicitis.
Why the study?
Subtle or atypical presentations make acute appendicitis challenging to diagnose, while abdominal USG is operator-dependent and CECT exposes patients to hazardous radiation.
Does a combined clinicoradiological score (Modified Alvarado Score + USG abdomen) reliably diagnose acute appendicitis in patients with right iliac fossa pain?
Observational (n=138)
No
Does a combined clinicoradiological score (Modified Alvarado Score + USG abdomen) reliably diagnose acute appendicitis in patients with right iliac fossa pain?
Effect estimate: AUC 0.875 (95% CI 0.802-0.948)
A combined scoring system using the Modified Alvarado Score and abdominal ultrasonography provides high diagnostic accuracy for acute appendicitis, potentially reducing the need for computed tomography.
May support limiting CT in high-score right iliac fossa pain; leaves open prospective validation of accuracy and outcomes.
Introduction Acute appendicitis is a common surgical emergency. Clinical assessment plays a major role; however, subtle clinical features in early stages and atypical presentation makes diagnosis challenging. Ultrasonography (USG) of the abdomen is a usual investigation that aids in diagnosis, however, it is operator dependent. A contrast-enhanced computed tomography (CECT) of the abdomen is more accurate; however, it exposes the patient to hazardous radiation. The study aimed to combine clinical assessment and USG abdomen in the reliable diagnosis of acute appendicitis. Objectives The objective of this study was to assess the diagnostic reliability of the Modified Alvarado Score and ultrasonography of the abdomen in acute appendicitis. Material and methods All patients with right iliac fossa pain, clinically suspected of having acute appendicitis, admitted to the department of general surgery, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, between January 2019 and July 2020, who gave consent were included. Clinically, Modified Alvarado Score (MAS) was calculated, after which patients were subjected to USG abdomen, where findings were noted and a sonologic score was calculated. The study group was the patients who needed appendicectomy (n=138). Operative findings were noted. Histopathological diagnosis of acute appendicitis was deemed as confirmatory in these cases and was correlated with MAS and USG scores to determine diagnostic accuracy. Results A combined clinicoradiological (MAS + USG) score of seven showed a sensitivity of 81.8% and a specificity of 100%. The specificity of score seven or above was 100%; however, the sensitivity at 81.8%. The diagnostic accuracy of the clinicoradiological was 87.5%. The negative appendicectomy rate was 4.34%, with a diagnosis of acute appendicitis being confirmed for 95.7% of patients upon histopathological examination. Conclusion The MAS and USG of the abdomen, which is an affordable and non-invasive tool, showed increased diagnostic reliability, and hence it can help reduce the use of CECT abdomen, as CECT abdomen is considered as a gold standard for confirmation or exclusion of diagnosis of acute appendicitis. Use of the combined scoring system of MAS and USG abdomen can be used as a cost-effective alternative.
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Bhardwaj et al. (2023) conducted an observational in Acute appendicitis (n=138). Combined Modified Alvarado Score (MAS) and Abdominal Ultrasonography (USG) vs. Histopathological diagnosis (Gold standard) was evaluated on Diagnostic accuracy (Area under the ROC curve) of combined MAS and USG score (AUC 0.875, 95% CI 0.802-0.948). A combined Modified Alvarado Score and abdominal ultrasonography score of seven or above yielded a diagnostic accuracy of 87.5% for acute appendicitis, with 81.8% sensitivity and 100% specificity.
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