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July 1, 2000Archives of Pathology & Laboratory Medicine

Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999.

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Authors

PFPatrick L. FitzgibbonsSt. Jude Medical CenterDPDL PageBreast Cancer Research FoundationDWDonald L. WeaverUniversity of Vermont

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Implication

Consensus statement identifies critical prognostic factors in breast cancer, guiding patient management and care improvements.

Key Points

  • The aim is to evaluate and categorize prognostic and predictive factors in breast cancer based on published evidence.
  • Factors were ranked into three categories: proven, extensively studied but unvalidated, and insufficiently studied.
  • Recommendations were made to improve tumor specimen evaluations and data collection.
  • A multidisciplinary group assessed various prognostic factors for breast cancer.
  • Category I included TNM staging, histologic grade, and hormone receptor status as critical prognostic indicators.
  • Category II encompassed factors like Her2-neu and proliferation markers, requiring further validation.
  • Category III included less studied factors like DNA ploidy and microvessel density with no proven value.

Cite This Study

Fitzgibbons et al. (2000) studied this question.

synapsesocial.com/papers/6a0b1baa334bc3615dacbcb4https://doi.org/10.5858/2000-124-0966-pfibc
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Also Consider

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  1. 1p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.1992 · 108 citations
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  3. 3Predictors of Recurrence and Survival of Patients with Breast Cancer1987 · 118 citations
  4. 4Factors influencing prognosis in node-negative breast carcinoma: analysis of 767 T1N0M0/T2N0M0 patients with long-term follow-up.1993 · 295 citations