What question did this study set out to answer?

Establish consensus recommendations for using hyaluronidase to manage vascular compromise and impending necrosis triggered by hyaluronic acid dermal filler injections.

May 10, 2015Aesthetic Surgery Journal

Treatment of Hyaluronic Acid Filler–Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations

View Full Paper

Ask AI

Bookmark

Authors

JCJoel L. CohenUniversity of Alabama at Birmingham BBBrian S. BiesmanNashville Oncology Associates SDSteven DayanUniversity of Illinois Chicago

Discussion

Member takes

Implication

Consensus recommendations report high-dose hyaluronidase protocols for vascular compromise after filler injections, highlighting the necessity of rapid intervention within 24 hours to prevent...

Key Points

Establish consensus recommendations for using hyaluronidase to manage vascular compromise and impending necrosis triggered by hyaluronic acid dermal filler injections.
Conducted a structured expert panel consensus based on an in-person roundtable discussion in Las Vegas, NV, and subsequent communications among experienced tertiary care clinicians.
Immediate administration of high-dose hyaluronidase (at least 200 U) without prior skin allergy testing is essential, with repeated dosing indicated if tissue perfusion does not improve within 60 minutes.
Adjunctive interventions to support revascularization include mechanical massage, warm compresses, dilution with lidocaine or saline to promote vasodilation and dispersion, and oral aspirin to inhibit clot progression.
Optimal tissue preservation and clinical outcomes occur when vascular compromise is recognized and definitively treated within 24 hours of injection.

Cite This Study

Cohen et al. (2015) studied this question.

synapsesocial.com/papers/6a0b2bc97e716524c8acce81 https://doi.org/10.1093/asj/sjv018

View Full Paper

Ask AI

Bookmark

Implication

Consensus recommendations report high-dose hyaluronidase protocols for vascular compromise after filler injections, highlighting the necessity of rapid intervention within 24 hours to prevent...

Treatment of Hyaluronic Acid Filler–Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment of Hyaluronic Acid Filler–Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider