Key result
4D flow MRI links BAV to ~220% higher circumferential WSS in the ascending aorta.
Observational (n=20)
A novel Laplacian finite element approach using 4D flow MRI data provides robust quantification of axial and circumferential wall shear stress, revealing a 220% increase in circumferential stress in the ascending aorta of BAV patients.
May inform biomechanical assessment in BAV aortopathy; leaves open clinical utility pending validation.
Purpose To decompose the 3D wall shear stress (WSS) vector field into its axial (WSS A ) and circumferential (WSS C ) components using a Laplacian finite element approach. Methods We validated our method with in silico experiments involving different geometries and a modified Poiseuille flow. We computed 3D maps of the WSS, WSS A , and WSS C using 4D flow MRI data obtained from 10 volunteers and 10 patients with bicuspid aortic valve (BAV). We compared our method with the centerline method. The mean value, standard deviation, root mean‐squared error, and Wilcoxon signed rank test are reported. Results We obtained an error <0.05% processing analytical geometries. We found good agreement between our method and the modified Poiseuille flow for the WSS, WSS A , and WSS C . We found statistically significance differences between our method and a 3D centerline method. In BAV patients, we found a 220% significant increase in the WSS C in the ascending aorta with respect to volunteers. Conclusion We developed a novel methodology to decompose the WSS vector in WSS A and WSS C in 3D domains, using 4D flow MRI data. Our method provides a more robust quantification of WSS A and WSS C in comparison with other reported methods. Magn Reson Med 79:2816–2823, 2018.
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Sotelo et al. (2017) conducted an observational in Bicuspid aortic valve (n=20). Laplacian finite element approach for 3D WSS decomposition vs. 3D centerline method / Healthy volunteers was evaluated on Wall shear stress (WSS) vector field decomposition into axial and circumferential components. A novel Laplacian finite element approach for decomposing 3D wall shear stress using 4D flow MRI revealed a 220% significant increase in circumferential WSS in the ascending aorta of BAV patients versus volunteers.
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